People with CVID have low levels of immune globulin (antibodies) and an increased risk for infection. Although the disease is usually diagnosed in adults, it can also occur in children.
CVID is also known by the following names:
Research has shown that CVID is more common in families with immune globulin A (IgA) deficiency; however, the causes of CVID have not been identified in more than 90 percent of cases.
Most people with CVID have frequent bacterial infections of the ears, sinuses, and lungs.
Some people also may have symptoms such as the following:
Doctors can diagnose CVID by weighing several factors:
People with CVID receive intravenous (through the vein) immune globulin every three to four weeks or subcutaneous (just under the skin) immune globulin weekly to restore normal antibody levels. The immune globulin given by either of these methods provides antibodies from about 60,000 healthy donors each time it is given. Bacterial infections are treated with antibiotics. Many patients need preventive antibiotics as well.